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Product Description
PDGFRA(platelet-derived growth factor receptor A), also termed PDGFRα(platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.
Biovision | P1460 | Human CellExp™ PDGF R alpha / PDGFRA, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: PDGFRA, CD140A, PDGFR2, RHEPDGFRA, MGC74795
Alternates names: PDGFRA, CD140A, PDGFR2, RHEPDGFRA, MGC74795
Taglines: Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells.
NCBI Gene ID #: 5156
NCBI Gene Symbol: P16234
Gene Source: Human
Accession #: P16234-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE.
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: Gln 24 - Ala 528
Handling: Centrifuge the vial prior to opening.
Usage:
