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Product Description
Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.
Biovision | P1470 | Human CellExp™ Properdin, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Properdin, Complement factor P, CFP, PFC
Alternates names: Properdin, Complement factor P, CFP, PFC
Taglines: A positive regulator of the alternate pathway of complement
NCBI Gene ID #: 5199
NCBI Gene Symbol: CFP
Gene Source: Human
Accession #: P27918
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage:
