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Product Description
Receptor activator of nuclear factor kappa-B ligand (RANK-L), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11) or CD254, is a member of the tumor necrosis factor (TNF) superfamily. Receptor activator of nuclear factor kappa-B ligand (RANK) and its ligand RANKL have been described for their key roles in bone metabolism, the central nervous system and the immune system. Subsequently, it has been shown that the RANKL-RANK system also plays a critical role in other bone pathologies, bone metastasis or hormone-driven breast cancer. RANK-L is a ligand for osteoprotegerin (OPG) and functions as a key factor for osteoclast differentiation and activation. Some studies suggest the expression of RANK-L allows sufficient microenvironmental conditions to influence cancer cell migration.
Biovision | P1552 | Human CellExp™ sRANK Ligand, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine
Alternates names: TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine
Taglines: Immune signaling facilitator
NCBI Gene ID #: 8600
NCBI Gene Symbol: OPGL
Gene Source: Human
Accession #: O14788
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE: ≥ 95%
Assay: SDS - PAGE
Purity: ≥ 95%
Assay #2: SEC
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 28 kDa (6xHis tag at the N-terminus)
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino acid sequence: Ala 145 – Asp 317
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
