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Product Description
Tau is a neuronal microtubule-associated protein. It stabilizes microtubules in axons. Tau protein become hyperphosphorylated and forms insoluble aggregates called neurofibrillary tangles in Alzheimer's disease. The accumulation of abnormal tau aggregates causes cytoxicity, which is described as a gain-of-toxic function model. Tau gene undergoes alternative splicing, giving rise to six different isoforms. Tau-352 isoform lacks exons 2, 3 and 10.
Biovision | P1622 | Human Tau-352 DataSheet
Biomolecule/Target :
Synonyms: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPTL; MTBT1; Tau 0N3R; tau isoform 4; ht23; 3RS tau
Alternates names: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPTL; MTBT1; Tau 0N3R; tau isoform 4; ht23; 3RS tau
Taglines: A tau isoform
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source: Human
Accession #: P10636, NP_058525
Recombinant: TRUE
Source: E.coli
Purity by SDS-PAGE: ≥ 85% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 38.9 kDa
Concentration:
Appearance: Liquid
Physical form description:
Reconstitution Instructions:
Amino acid sequence: The target protein is expressed with the sequence (aa 1-352) of human tau-352 fused to His-tag at the N-terminus.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
