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Product Description
TLR4 is a member of Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR4 receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Biovision | P1417 | TLR4 / CD284, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: ARMD10, CD284, TLR-4, TLR4, TOLL
Alternates names: ARMD10, CD284, TLR-4, TLR4, TOLL
Taglines: TLR family member which plays a fundamental role in pathogen recognition and activation of innate immunity
NCBI Gene ID #: 7099
NCBI Gene Symbol: TLR4
Gene Source: Human
Accession #: O00206
Recombinant: True
Source: Insect Cells (sf9)
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE.
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA. The concentration of human recombinant MD2 that produces 50% optimal binding response with immobilized human recombinant TLR4 at 2 ug/mL (100 uL/well) is approximately 0.5 ug/mL.
Biological activity:
Results:
Binding Capacity: Measured by its binding ability in a functional ELISA. The concentration of human recombinant MD2 that produces 50% optimal binding response with immobilized human recombinant TLR4 at 2 ug/mL (100 uL/well) is approximately 0.5 ug/mL.
Unit Definition:
Molecular Weight: 70.5 kDa (C terminal 6x His tag)
Concentration:
Appearance: Sterile Filtered colorless solution
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: aa 24-631
Handling: Centrifuge the vial prior to opening.
Usage:
