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Biovision

  • AMG-337

    Biovision | AMG-337 | B3317

    AMG-337 is a potent and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, that subsequently blocks downstream PI3K and MAPK pathways. It has been...

    NULL288.00 - NULL894.00
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  • Glumetinib

    Biovision | Glumetinib | B2561

    Glumetinib (SCC-244) is a potent and highly selective inhibitor of c-Met kinase (IC₅₀ = 0.42 nM). Glumetinib displays subnanomolar potency against c-Met kinase activity and high selectivity versus...

    NULL303.00 - NULL959.00
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  • SAR-125844

    Biovision | SAR-125844 | B2510

    SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous...

    NULL205.00 - NULL533.00
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  • SU 11274

    Biovision | SU 11274 | 1938

    A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC₅₀ values: Met...

    NULL320.00 - NULL1,009.00
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  • Carbozantinib

    Biovision | Carbozantinib | 1935

    Cell-permeable. A potent inhibitor of MET, vascular endothelial growth factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, and anti-invasive effects.Carbozantinib is a potent...

    NULL296.00 - NULL910.00
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  • BMS-777607

    Biovision | BMS-777607 | 2455

    A potent, selective and ATP-competitive Met kinase superfamily inhibitor (IC₅₀ = 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM for c-Met, Axl, RON, and Tyro-3, respectively). it was >40-fold selective for Met...

    NULL288.00 - NULL861.00
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  • Altiratinib

    Biovision | Altiratinib | 9563

    Altiratinib is a selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET...

    NULL288.00 - NULL894.00
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  • Crizotinib

    Biovision | Crizotinib | 1934

    A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at...

    NULL296.00 - NULL910.00
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  • Tivantinib

    Biovision | Tivantinib | B1546

    Tivantinib (ARQ-197) is a potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity. Tivantinib binds to the c-Met protein and disrupts c-Met signal transduction pathways,...

    NULL222.00 - NULL631.00
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  • JNJ-38877605

    Biovision | JNJ-38877605 | B2063

    JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays...

    NULL354.00 - NULL1,148.00
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  • Golvatinib

    Biovision | Golvatinib | 2655

    Golvatinib ( E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with...

    NULL320.00 - NULL984.00
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  • AMG-208

    Biovision | AMG-208 | 2553

    AMG-708 is a selective small-molecule inhibitor (IC₅₀ = 9.3 nM) of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent...

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  • PF-04217903

    Biovision | PF-04217903 | B2062

    PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903...

    NULL271.00 - NULL828.00
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  • PHA-665752

    Biovision | PHA-665752 | B2057

    PHA-665752 is a potent, selective and ATP-competitive inhibitor of MET kinase (IC₅₀ values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively...

    NULL303.00 - NULL959.00
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  • Foretinib

    Biovision | Foretinib | 9476

    Foretinib is an ATP-competitive multi-kinase inhibitor that suppresses the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In...

    NULL239.00 - NULL697.00
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