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Biovision

  • Cilastatin

    Biovision | Cilastatin | B2689

    Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial...

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  • Doripenem

    Biovision | Doripenem | B2688

    Doripenem is a broad-spectrum β-lactam antibiotic. It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae. Doripenem reduces the...

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  • Cloxacillin sodium

    Biovision | Cloxacillin sodium | B2687

    Cloxacillin sodium is a β-lactam antibiotic of penicillin subclass, which inhibits bacterial cell wall synthesis by targeting the proteoglycan synthesis. Cloxacillin has a narrow spectrum of action...

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  • Formoterol

    Biovision | Formoterol | B2686

    Formoterol is a ß2-adrenergic agonist, and a long-term bronchodilator. It demonstrates a 330-fold selectivity for β2 over β1 receptors. Formoterol is used to manage asthma and in the treatment of...

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  • Natamycin

    Biovision | Natamycin | B2685

    Natamycin is a naturally-occurring macrolide polyene antibiotic that acts as an antifungal agent. Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of...

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  • Cidofovir

    Biovision | Cidofovir | B2682

    Cidofovir is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into...

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  • Reserpine

    Biovision | Reserpine | B2681

    Reserpine is an alkaloid isolated from dried roots of R. serpentine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM,...

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  • Emtricitabine

    Biovision | Emtricitabine | B2678

    Emtricitabine is a cytidine analog that acts as an inhibitor of reverse transcriptase, preventing replication of HIV-1 (EC50 = 10-20 nM) and hepatitis B (EC50 = 10-40 nM). It is activated through...

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  • Olanzapine

    Biovision | Olanzapine | B2677

    Olanzapine is an antipsychotic agent with anticholinergic properties. It binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor...

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  • iFSP1

    Biovision | iFSP1 | B2676

    iFSP1 inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer...

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  • Dibromobimane

    Biovision | Dibromobimane | B2673

    Dibromobimane, a bifunctional thiol-reactive fluorescent reagent that is used as a cross-linking agent for cysteine mapping and studies on protein structure/conformation and cross-linking processes...

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  • Monobromobimane

    Biovision | Monobromobimane | B2672

    Monobromobimane (mBBr) is a cell-permeable, thiol-reactive fluorescent probe that is widely used to detect various thiol-containing biomolecules such as glutathione in cells. It reacts rapidly at...

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  • Monochlorobimane

    Biovision | Monochlorobimane | B2671

    Monochlorobimane is a cell-permeant probe for quantifying glutathione levels in cells. It is essentially nonfluorescent until it reacts with a thiol group. It readily reacts with several low...

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  • CA-1001

    Biovision | CA-1001 | B2669

    CA-1001 is a neutral ionophore with high selectivity for Ca²⁺ ions. CA-1001 can be used in microelectrodes for the determination of intracellular Ca2+-activities and of slowly changing Ca²⁺ levels...

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  • MI-463

    Biovision | MI-463 | B2668

    MI-463 is a potent inhibitor of Menin-MLL interaction (IC₅₀ = 15.3 nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through...

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  • BAY-598

    Biovision | BAY-598 | B2667

    BAY-598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC₅₀ values are 27 and 58 nM for biochemical and cellular activity assays, respectively). It displays...

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  • ML-216

    Biovision | ML-216 | B2666

    ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At...

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  • NSC-19630

    Biovision | NSC-19630 | B2665

    NSC-19630 (MIRA-1) is a cell-permeable inhibitor of Werner syndrome WRN helicase activity (IC₅₀ = 20 µM) over its ATPase and exonuclease activities, but did not affect other DNA helicases [Bloom...

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  • NSC-617145

    Biovision | NSC-617145 | B2664

    NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is...

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  • CDE-096

    Biovision | CDE-096 | B2663

    CDE-096 is a high affinity, synthetic inactivator of plasminogen activator inhibitor-1 (PAI-1). CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding...

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  • Dutasteride

    Biovision | Dutasteride | B2662

    Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural...

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  • Cytarabine

    Biovision | Cytarabine | B2661

    Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor...

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  • Pirfenidone

    Biovision | Pirfenidone | B2660

    Pirfenidone is a small molecule antifibrotic agent. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines...

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  • Carmustine

    Biovision | Carmustine | B2658

    Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading...

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  • Teniposide

    Biovision | Teniposide | B2655

    Teniposide is a podophyllotoxin derivative that acts as a topoisomerase II inhibitor. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA...

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  • Methotrexate

    Biovision | Methotrexate | B2654

    Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division...

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  • Ifosfamide

    Biovision | Ifosfamide | B2653

    Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Like...

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  • Eflornithine

    Biovision | Eflornithine | B2651

    Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits...

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  • Doxifluridine

    Biovision | Doxifluridine | B2650

    Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid...

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  • Deferasirox

    Biovision | Deferasirox | B2649

    Deferasirox is an orally bioavailable tridentate iron chelator. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels...

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  • Fotemustine

    Biovision | Fotemustine | B2648

    Fotemustine is a third generation nitrosourea, chloroethylating agent with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine,...

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  • XMD8-87

    Biovision | XMD8-87 | B2647

    XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of...

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  • WAY-316606

    Biovision | WAY-316606 | B2646

    WAY-316606 is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM). It blocks sFRP-1 from interacting with Wnt and thus increases Wnt signaling.WAY-316606 is a secreted...

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  • i-CRT3

    Biovision | i-CRT3 | B2645

    i-CRT3 is a small cell-permeable oxazole derivative that acts as an inhibitor of both Wnt and β-catenin-responsive transcription.i-CRT3 is a small cell-permeable oxazole derivative that acts as an...

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  • LF3

    Biovision | LF3 | B2644

    LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in...

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  • NCB-0846

    Biovision | NCB-0846 | B2643

    NCB-0846 is a potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3,...

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  • Hydroxy Dynasore

    Biovision | Hydroxy Dynasore | B2642

    Hydroxy Dynasore is an analog of Dynasore (Cat. No. 1900) that acts as a potent dynamin inhibitor (IC₅₀ values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated...

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  • LDN-212854

    Biovision | LDN-212854 | B2641

    LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in...

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  • Atovaquone

    Biovision | Atovaquone | B2640

    Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P...

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  • DSM265

    Biovision | DSM265 | B2639

    DSM265 is a potent, selective and long duration dihydroorotate dehydrogenase (DHODH)) inhibitor (IC₅₀ = 8.9 nM). DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is...

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  • Rogaratinib

    Biovision | Rogaratinib | B2638

    Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR)...

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