Product Description
Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
Biovision | B2650 | Doxifluridine DataSheet
Alternate Name/Synonyms: Furtulon; 5'-Deoxy-5-fluorouridine; 5-fluoro-5'-deoxyuridine
Appearance: White solid
Formulation:
CAS Number: 3094-09-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₉H₁₁FN₂O₅
Molecular Weight: 246.19
Cell-Permeable?: True
Purity: ≥98%
Solubilities: >10 mg/ml in DMSO, >20 mg/ml in Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An oral prodrug of the antineoplastic agent 5-fluorouracil
MDL Number: MFCD00866530
PubChem CID: 18343
SMILES: CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O
InChi: InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1
InChi Key: ZWAOHEXOSAUJHY-ZIYNGMLESA-N