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Biovision

  • α-Mangostin

    Biovision | α-Mangostin | B1059

    α-Mangostin, a naturally occurring xanthone, displays both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with an IC50 value of 5.54 μM noncompetitively...

    $949 - $2,898
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  • Z-YVAD-FMK

    Biovision | Z-YVAD-FMK | 1141

    A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in...

    $1,894 - $4,477
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  • Z-VRPR-FMK

    Biovision | Z-VRPR-FMK | B1238

    Z-VRPR-FMK is selective and irreversible MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor that inhibits NF- κB dependent gene expression affecting the growth,...

    $1,813 - $4,851
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  • Z-VEID-FMK

    Biovision | Z-VEID-FMK | 1146

    VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant...

    $1,635 - $4,277
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  • Z-VDVAD-FMK

    Biovision | Z-VDVAD-FMK | 1142

    A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in...

    $1,694 - $4,477
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  • Z-VAD-FMK

    Biovision | Z-VAD-FMK | 1140

    A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can...

    $1,635 - $4,477
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  • ZnAF-2, 6-Iso

    Biovision | ZnAF-2, 6-Iso | 2756

    ZnAF-2, 6-iso-, is a cell-impermeable compound that acts as a high-affinity Zn²⁺-specific fluorescent probe (Kd = 2.7 nM). It shows low basal fluorescence and the fluorescence intensity increases...

    $837 - $2,440
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  • ZM 447439

    Biovision | ZM 447439 | 2018

    Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other...

    $749 - $2,065
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  • Z-LEVD-FMK

    Biovision | Z-LEVD-FMK | 1144

    A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be...

    $1,694 - $4,277
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  • Z-LEHD-FMK

    Biovision | Z-LEHD-FMK | 1149

    A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on...

    $1,694 - $4,074
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  • Zinpyr-1

    Biovision | Zinpyr-1 | 2754

    Zinpyr-1 is a membrane-permeable fluorophore suitable for the fluorometric detection of free Zn²⁺. In living cells, Zinpyr-1 mainly stains the Golgi or a Golgi-associated vesicle.Zinpyr-1 is a...

    $1,120 - $3,584
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  • Z-FA-FMK

    Biovision | Z-FA-FMK | 1986

    Cell-permeable. A useful negative control for FMK-labeled caspase inhibitors. Also, an irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain.Z-FA-FMK...

    $809 - $1,985
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  • Z-ATAD-FMK

    Biovision | Z-ATAD-FMK | 1152

    A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is...

    $1,866 - $4,851
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  • Z-AEVD-FMK

    Biovision | Z-AEVD-FMK | B1162

    Z-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies...

    $1,813 - $4,851
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  • YM201636

    Biovision | YM201636 | 2045

    Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC50 = 33 nM). It inhibits p110α at higher concentration (IC50 = 3 µM). It reversibly impairs endosomal...

    $690 - $1,813
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  • YM155

    Biovision | YM155 | 2310

    YM155 is a novel small molecule survivin suppressant; suppresses the expression of surviving and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L.YM155 is a novel small molecule...

    $718 - $1,985
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  • YC-1

    Biovision | YC-1 | 2061

    Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured...

    $809 - $2,268
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  • XL765

    Biovision | XL765 | 2551

    XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in...

    $1,120 - $3,584
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  • XL-647

    Biovision | XL-647 | B2204

    XL-647 is an orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. It binds to and inhibits several receptor tyrosine kinases that play...

    $777 - $2,156
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  • XL-228

    Biovision | XL-228 | 2632

    XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It...

    $718 - $1,985
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  • XL-147

    Biovision | XL-147 | 9401

    XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617,...

    $1,239 - $3,703
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  • Xestospongin C

    Biovision | Xestospongin C | 2621

    Xestospongin C is a marine natural product isolated from Pacific basin sponges; it antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Xestospongin C...

    $1,292 - $3,703
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  • WZ-8040

    Biovision | WZ-8040 | B2205

    WZ-8040 is a potent EGFR inhibitor that suppresses the growth of EGFR-T790M (a mutation of the gatekeeper T790 residue) containing cell lines and inhibits EGFR phosphorylation.WZ-8040 is a potent...

    $1,120 - $3,584
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  • WY-14643

    Biovision | WY-14643 | 2041

    Cell-permeable. A selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively.WY-14643 is a selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at...

    $690 - $1,754
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  • WST-3

    Biovision | WST-3 | 2814

    WST-3 is a highly sensitive tetrazolium reagent that produces a water-soluble, colored formazan dye with reducing agents such as NADH.WST-3 is a highly sensitive tetrazolium reagent that produces a...

    $1,180 - $6,741
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  • WST-1

    Biovision | WST-1 | 2198

    A water-soluble tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the corresponding...

    $749 - $1,351
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  • WP-1130

    Biovision | WP-1130 | 2014

    Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein...

    $749 - $2,065
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  • WIKI-4

    Biovision | WIKI-4 | B1630

    WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50...

    $749 - $2,037
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  • WHI-P131

    Biovision | WHI-P131 | 1853

    Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also...

    $1,036 - $2,671
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  • WDR5 0103

    Biovision | WDR5 0103 | B1125

    WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM). It inhibits the catalytic activity of MLL core complex in in vitro experiments with IC₅₀ of 39 µM. WDR5 is a...

    $1,061 - $3,357
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  • WAY-362450

    Biovision | WAY-362450 | B1631

    WAY-362450 is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is a highly potent, selective, and orally active farnesoid X receptor...

    $1,152 - $3,703
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  • WAY-170523

    Biovision | WAY-170523 | 9607

    WAY-170523 is a potent and selective inhibitor of MMP-13 (IC₅₀ = 17 nM). Inhibits MMP-9, TACE and MMP-1 only at higher concentrations (IC₅₀ values of 945, >1000 and >10,000 nM, respectively)...

    $1,008 - $3,129
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  • VX-809

    Biovision | VX-809 | 2857

    VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and...

    $1,008 - $3,129
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  • VX-765

    Biovision | VX-765 | 2781

    VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against...

    $949 - $2,898
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  • VX-745

    Biovision | VX-745 | 2812

    VX-745 is a potent and selective inhibitor of p38α (IC₅₀ = 10 nM). It displays 22-fold greater selectivity versus p38β and no inhibition of p38γ. Also blocks TNFα production in LPS-stimulated HWB in...

    $1,008 - $3,070
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  • VX-661

    Biovision | VX-661 | B1268

    VX-661, is CFTR modulator that is potentially useful for treatment of cystic fibrosis. VX-661 corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro.VX-661, is CFTR...

    $949 - $2,898
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  • VU0155041

    Biovision | VU0155041 | B1299

    VU0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC₅₀ = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of...

    $718 - $1,985
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  • VK3-OCH3

    Biovision | VK3-OCH3 | 2694

    VK3-OCH3 is a Vitamin K3 (Menadione) analog that displays potent antitumor activity. It has been shown to induce G2/M arrest and apoptosis in neuroblastoma cells with much less cytotoxicity towards...

    $837 - $2,440
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