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Product Description
GPR43 polyclonal Antibody | BS65586 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Pig,Rabbit,
Application: WB,
Application Range: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Background: G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor (GPR) GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. GPR43 functions as a ligand for short chain fatty acids (SCFAs), notably acetate and propionate. Bacteria in the gut produce high concentrations of SCFAs, which are subsequently released in the bloodstream, where they exert cellular effects on blood leukocytes, including calcium release, ERK1/2 activation, and inhibition of cAMP accumulation. These effects indicate a role for GPR43 in the recruitment of leukocytes, particularly polymorphonuclear cells, to sites of bacterial infection.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GPR43 polyclonal Antibody detects endogenous levels of GPR43 protein.
Molecular Weight: ~43kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: GPCR GPR43; FFA2R; Ffar2; FFAR2_HUMAN; free fatty acid activated receptor 2; Free fatty acid receptor 2; G protein coupled receptor 43; G protein-coupled receptor 43; G-protein coupled receptor 43; GPR 43; GPCR 43.
Immunogen: KLH conjugated synthetic peptide derived from human GPR43:21-120/330
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway:
