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Product Description
STAT3 (Phospho-Tyr705) polyclonal Antibody | BS94057 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: STAT3 (Phospho-Tyr705) polyclonal Antibody detects endogenous levels of STAT3 protein only when phosphorylated at Tyr705.
Molecular Weight: 88 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: STAT3, 1110034C02Rik, Acute Phase Response Factor, Acute-phase response factor, ADMIO, APRF, AW109958, DNA binding protein APRF, FLJ20882, HIES, MGC16063, Signal transducer and activator of transcription 3 (acute phase response factor), Signal transducer and activator of transcription 3, STAT 3, Stat3, STAT3,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Tyr705 of human STAT3.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: ProA affinity purified
Pathway:
