Product Description
VP16 tagPolyclonal Antibody | BS65868 | Bioworld
Host: Rabbit
Reactivity: Human herpesvirus 1
Application: WB,
Application Range: WB=1:500-2000
Background: HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.
Storage & Stability: Store at 4°C short term. Aliquot and store at -41°C long term. Avoid freeze-thaw cycles.
Specificity: VP16 tag Polyclonal Antibody detects endogenous levels of VP16 tag protein.
Molecular Weight: ~51 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: VP16_HHV1F;UL48; Tegument protein VP16; Alpha trans-inducing protein; Alpha-TIF; ICP25; Vmw65
Immunogen: KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: