Product Description
AKIRIN1 Polyclonal Antibody | BS65445 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Dog,Horse,Sheep,
Application: IHC-P,
Application Range: IHC-P=1:100-500
Background: AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: AKIRIN1 Polyclonal Antibody detects endogenous levels of AKIRIN1 protein.
Molecular Weight: 22kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.
Immunogen: KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: