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Product Description
ATF2 (phospho-T69) polyclonal Antibody | BS4017 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC IP
Application Range: IHC: 1:50~1:200 IP: 1:50~1:200
Background: The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-ATF2 (T69) polyclonal Antibody detects endogenous levels of ATF2 protein only when phosphorylated at Thr69.
Molecular Weight: ~ 55 to 75 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1; ATF-2; CREB2; CREBP1
Immunogen: Synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Threonine 69.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Signaling Pathways Activating p38 MAP Kinase,
