Product Description
Caspase-1 polyclonal Antibody | BS90183 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC FC
Application Range: WB:1:1,000-1:2,000 FC:1:50-1:100 IHC:1:50-1:200
Background: Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10) 2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Caspase-1 polyclonal Antibody detects endogenous levels of Caspase-1 protein.
Molecular Weight: 45 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CASP-1, IL-1BC, ICE, IL-1 beta-converting enzyme, CASP1, CASP-1, CASP1, CASP1, Caspase 1, Caspase-1 subunit p10, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1 beta converting enzyme, IL1B convertase, Interleukin 1 beta convertase, Interleukin 1B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: