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Product Description
CRM1 polyclonal Antibody | BS90332 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IF IHC FC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:100 FC:1:50-1:100
Background: Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha1 and karyopherin beta1 subunits. p62 glycoprotein is a nucleoporin that is not only involved in the nuclear import of proteins, but also the export of nascent mRNA strands. NTF2 (nuclear transport factor 2) interacts with nucleoporin p62 as a homodimer composed of two monomers, and may be an obligate component of functional p62. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES) .
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: CRM1 polyclonal Antibody detects endogenous levels of CRM1 protein.
Molecular Weight: 123 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Exp1, XPO1, CRM1, Chromosome region maintenance 1 protein homolog, CRM 1, CRM1 homolog, DKFZp686B1823, emb, Exp 1, Exp1, Exportin 1, Exportin-1, Exportin1, XPO 1, xpo1, XPO1,
Immunogen: Recombinant protein within C terminal human CRM1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
