Product Description
NPY2-R (D42) polyclonal Antibody | BS2818 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC IF
Application Range: IHC: 1:50~1:200 IF: 1:50~1:200
Background: NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31% sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity),NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: NPY2-R (D42) polyclonal Antibody detects endogenous levels of NPY2-R protein.
Molecular Weight: ~ 43 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Neuropeptide Y receptor type 2; NPY2-R; NPY-Y2 receptor; Y2 receptor; NPY2R
Immunogen: Synthetic peptide, corresponding to amino acids 30-80 of Human NPY2-R.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: