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Product Description
Phospho-LRP6 (Thr1479) Polyclonal Antibody | BS65913 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,
Application: FCM,
Application Range: Flow-Cyt=0.2ug/test
Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Phospho-LRP6 (Thr1479) Polyclonal Antibody detects endogenous levels of LRP6 protein only when phosphorylated at Thr1479.
Molecular Weight: 175kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: LRP6 (Phospho-Thr1479) ; LRP6 (Phospho-T1479) ; p-LRP6 (Thr1479) ; p-LRP6 (T1479) ; ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6.
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG (p-T) YF
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: affinity purified by Protein A
Pathway:
