Product Description
SKOR2 Polyclonal Antibody | BS65800 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,
Application: IHC-P,
Application Range: IHC-P=1:100-500
Background: The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-尾 by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-尾 in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3.
Storage & Stability: Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles.
Specificity: SKOR2 Polyclonal Antibody detects endogenous levels of SKOR2 protein.
Molecular Weight: ~104 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN
Immunogen: KLH conjugated synthetic peptide derived from human SKOR2:871-970/100
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: