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Product Description
Cytochrome c polyclonal Antibody | BS6440 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: Cytochrome c is a well characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial intermembrane space. More recent studies have identifed cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is translocated from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32) . Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Cytochrome c polyclonal Antibody detects endogenous levels of Cytochrome c protein.
Molecular Weight: ~ 14 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cytochrome c; CYCS; CYC
Immunogen: Recombinant full length Human Cytochrome c.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Nuclear Receptor Signaling,
![Cytochrome c Antibody [Polyclonal] | PC-060](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/391113/569576/klogo__76714.1643661101__06355.1644059219.png?c=2 "Cytochrome c Antibody [Polyclonal] | PC-060")
