Product Description
DPYSL4 polyclonal Antibody | BS65335 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
Application Range: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Background: disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND) . PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CRMP-3 Polyclonal Antibody detects endogenous levels of CRMP-3 protein.
Molecular Weight: ~ 62 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: DPYSL4; CRMP3; ULIP4; Dihydropyrimidinase-related protein 4; DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4
Immunogen: The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Pathway: