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Product Description
Dynamin-1 (V768) polyclonal Antibody | BS1396 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Dynamin-1 (V768) polyclonal Antibody detects endogenous levels of Dynamin-1 protein.
Molecular Weight: ~ 98 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Dynamin 1; Dynamin1; DNM1; DNM; Dynamin I; Dynamin-I; DynaminI
Immunogen: Synthetic peptide, corresponding to amino acids 750-800 of Human Dynamin-1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Cell Cycle Control G1 S Checkpoint,
