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Product Description
Fes polyclonal Antibody | BS7116 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB
Application Range: WB 1:500 - 1:2000
Background: FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Fes polyclonal Antibody detects endogenous levels of Fes protein.
Molecular Weight: ~ 98 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Proto-oncogene tyrosine-protein kinase FES/FPS; C-FES
Immunogen: Recombinant full length Human Fes.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
