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Product Description
FGFR4 (phospho-Y642) polyclonal Antibody | BS64391 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB: 1:500~1:1000
Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligandbinding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-4, unlike the other FGFR genes, is alternatively spliced to produce only one isoform. It is expressed in fetal adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues. FGFR-4 is also overexpressed in breast cancers and, subsequently, is a potential target for drug therapy.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: FGFR4 (phospho-Y642) polyclonal Antibody detects endogenous levels of FGFR4 protein only when phosphorylated at Try642 .
Molecular Weight: ~ 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Fibroblast growth factor receptor 4 ; FGFR-4; CD334; FGFR4; JTK2; TKF
Immunogen: Synthetic phosphopeptide derived from human FGFR4 around the phosphorylation site of Tyrosine642.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Translational Contral elF4 and p70 S6 Kinase,Insulin &Glucose Signaling,
