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Product Description
FOSB (Phospho-S27) polyclonal Antibody | BS64527 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IHC IF
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: FOSB (Phospho-S27) polyclonal Antibody detects endogenous levels of FOSB protein only when phosphorylated at Ser27.
Molecular Weight: ~ 36 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Protein fosB; G0/G1 switch regulatory protein 3; FOSB; G0S3
Immunogen: Synthetic phosphopeptide derived from human FOSB around the phosphorylation site of Serine 27.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Notch Signaling,Nuclear Receptor Signaling,Epigenetic Writers and Erasers of Histone H3,
