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Product Description
PDGFR-α (phospho-Y754) polyclonal Antibody | BS74007 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB 1:500 - 1:2000
Background: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PDGFR-α (phospho-Y754) polyclonal Antibody detects endogenous levels of PDGFR-α protein only when phosphorylated at Tyr754.
Molecular Weight: ~ 180 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CD140A; PDGFR2; PDGFR-2; RHEPDGFRA;
Immunogen: A phospho specific peptide corresponding to residues surrounding Y754 of human PDGFRA.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Tumor Angiogenesis,
