Product Description
5HT2C Receptor polyclonal Antibody | BS90010 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC
Application Range: WB:1:500-1:2,000 IHC:1:50-1:200
Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: 5HT2C Receptor polyclonal Antibody detects endogenous levels of 5HT2C Receptor protein.
Molecular Weight: 70 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: 5-HT-2C, 5-HT2C, 5-HTR2C, 5-HT-1C, 5-HT1C, HTR2C, HTR1C, 5 Hydroxytryptamine 2C receptor, 5-HT-1C, 5-ht-1c receptor, 5-HT-2C, 5-HT1C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2C, 5HT1C, 5HT2C, 5HT2C, 5HTR2C, 5Hydroxytryptamine 2C receptor, Htr1c, HTR2C, serotonin 1c receptor, serotonin 2c receptor, Serotonin 5-HT-2C receptor, Serotonin receptor 2C,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: