Euro
USD
British Pound
NULL
Product Description
ACER1 polyclonal Antibody | BS60096 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: ASAH3 (N-acylsphingosine amidohydrolase (alkaline ceramidase) 3), also designated ACER1, is a 264 amino acid multi-pass membrane protein that localizes to the membrane of the endoplasmic reticulum. Expressed predominately in epidermal tissue, ASAH3 catalyzes the hydrolysis of the sphingolipid ceramide into sphingosine and a free fatty acid, thereby playing an important role in the regulation of bioactive ceramide and sphingosine levels within the cell. ASAH3 functions at an optimal pH of 8.0 and has high specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine, but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ACER1 polyclonal Antibody detects endogenous levels of ACER1 protein.
Molecular Weight: ~ 50 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; EC=3.5.1.23; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; ACER1; ASAH3
Immunogen: A synthetic peptide corresponding to residues in Human ACER1
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
