Product Description
AFF1 polyclonal Antibody | BS8592 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC IF
Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
Background: Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: AFF1 polyclonal Antibody detects endogenous levels of AFF1 protein.
Molecular Weight: ~ 131kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4; AFF1; AF4, FEL, MLLT2, PBM1
Immunogen: Recombinant full length Human AFF1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: