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Product Description
PDPK1 (phospho-S241) polyclonal Antibody | BS4155 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-PDPK1 (S241) polyclonal Antibody detects endogenous levels of PDPK1 protein when phosphorylated at Ser241.
Molecular Weight: ~ 63 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: 3-phosphoinositide-dependent protein kinase 1; hPDK1; PDPK1; PDK1
Immunogen: Synthetic phosphopeptide derived from human PDPK1 around the phosphorylation site of Serine 241.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Phosphoinosotode Signaling,Protein Kinase C Signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,Mitochondrial Control of Apoptosis,
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