Product Description
Reelin polyclonal Antibody | BS91164 | Bioworld
Host: Rabbit
Reactivity: Human, Rat
Application: WB IHC
Application Range: WB:1:500-1:1,000 IHC:1:50-1:200
Background: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in "reeler" mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Reelin polyclonal Antibody detects endogenous levels of Reelin protein.
Molecular Weight: 388 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: RELN, LIS2, PRO1598, Reeler, Reelin, RELN, RELN, RL,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: