Product Description
SLC25A12 polyclonal Antibody | BS5616 | Bioworld
Host: Rabbit
Reactivity: Human,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca (2+) entry in mitochondria via the Ca (2+) uniporter followed by Ca (2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca (2+) -binding mitochondrial aspartate-glutamate carrier, has Ca (2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS) . ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca (2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SLC25A12 polyclonal Antibody detects endogenous levels of SLC25A12 protein.
Molecular Weight: ~ 74 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12; ARALAR1
Immunogen: Synthetic peptide, corresponding to amino acids 435-480 of Human SLC25A12.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: ErbB HER Signaling,