Product Description
MBD2 polyclonal Antibody | BS71685 | Bioworld
Host: Rabbit
Reactivity: Mouse,Rat
Application: WB
Application Range: WB 1:500 - 1:2000
Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MBD2 polyclonal Antibody detects endogenous levels of MBD2 protein.
Molecular Weight: Predicted band size: 43 kDa Observed band size: Refer to Figures
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: DMTase; NY-CO-41
Immunogen: A synthetic peptide of human MBD2
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: