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Product Description
CD86 (7H3) monoclonal Antibody | MB8608 | Bioworld
Host: Mouse
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:5000~1:2000
Background: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins B7-1 (CD80) and B7-2 (CD86) expressed on antigen presenting cells bind the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28, and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CD86 (7H3) monoclonal Antibody detects endogenous levels of CD86 protein.
Molecular Weight: ~ 70 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD86
Immunogen: Synthetic peptide, corresponding to amino acids of Human CD86.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
![CD86 Monoclonal Antibody [RMC965A] | A68432](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/136118/553960/epigentek__99935.1643835436__44999.1643836862.png?c=2 "CD86 Monoclonal Antibody [RMC965A] | A68432")
