Product Description
ERα polyclonal Antibody | BS90478 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IHC FC
Application Range: WB:1:500-1:1,000 ICC:1:50 IHC:1:50-1:200 FC:1:50-1:100
Background: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.
Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Specificity: ERα polyclonal Antibody detects endogenous levels of ERα protein.
Molecular Weight: 66/54/48/36 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ER, ESR1, ESR, NR3A1., DKFZp686N23123, ER alpha, ER, ER-alpha, Era, ESR, ESR1, ESR1, ESRA, Estradiol receptor, Estrogen nuclear receptor alpha, Estrogen receptor 1, Estrogen receptor alpha 3*, 4, 5, 6, 7*/822 isoform, Estrogen receptor alpha, Estrogen receptor alpha delta 3*, 4, 5, 6, 7*, 8*/941 isoform, Estrogen receptor alpha delta 3*, 4, 5, 6, 7*/819 2 isoform, Estrogen receptor alpha delta 4 +49 isoform, Estrogen receptor alpha delta 4*, 5, 6, 7*/654 isoform, Estrogen receptor alpha delta 4*, 5, 6, 7, 8*/901 isoform, Estrogen receptor alpha E1 E2 1 2, Estrogen receptor alpha E1 N2 E2 1 2, Estrogen receptor, ESTRR, NR3A1, Nuclear receptor subfamily 3 group A member 1 Antibody
Immunogen: Recombinant protein within Human Estrogen Receptor alpha aa 1-120.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein affinity purified.
Pathway: