Product Description
FEN1 (7H8) monoclonal Antibody | MB0179 | Bioworld
Host: Mouse
Reactivity: Human,Mouse,Rat
Application: WB ICC
Application Range: WB: 1:1000 ICC: 1:1000~500
Background: DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. FEN-1 (for flap endonuclease) is an endonuclease that specifically cleaves the 5' flap structure of DNA in the process of DNA repair. FEN-1 is highly homologous to yeast Rad2. The C-terminal region of FEN-1 may bind to PCNA, thus allowing FEN-1 to function as an exonuclease in DNA replication.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of FEN1 and does not cross-react with related proteins.
Molecular Weight: Predicted band size:42KDa Observed band size:42KDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1; FEN1; RAD2
Immunogen: Purified recombinant human FEN-1 protein fragments expressed in E.coli.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: ATP-Dependent Chromatin Remodeling Complexes,