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Product Description
FMRP polyclonal Antibody | BS90520 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC
Application Range: WB:1:5,000-1:10,000 ICC:1:100-1:500 IHC:1:50-1:200
Background: Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box) . FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: FMRP polyclonal Antibody detects endogenous levels of FMRP protein.
Molecular Weight: 71 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: FMRP, Protein FMR-1, FMR1, FMR 1, Fmr1, Fmr1 gene, FMR1, FMRP, Fragile X mental retardation 1, Fragile X mental retardation 1 protein, Fragile X mental retardation protein 1, Fragile X mental retardation protein, fragile X mental retardation syndrome-related protein 1, fragile X mental retardation, autosomal homolog 1, FRAXA, fxr1, MGC87458, POF, POF1, Protein FMR-1, Protein FMR1, wu:fb16f11, wu:fd18c10, zgc:66226,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
