Product Description
KMT5A polyclonal Antibody | BS90775 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse
Application: WB FC
Application Range: WB:1:500-1:2,000 FC:1:50-1:100
Background: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. All monomethylates 'Lys-20' of histone H4 (H4K20me1) . H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, benef playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contribute to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53 / TP53 at 'Lys-382', leading to repress p53 / TP53-target genes.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: KMT5A polyclonal Antibody detects endogenous levels of KMT5A protein.
Molecular Weight: N/A
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PR-Set7, PR/SET07, KMT5A, PRSET7, SET07, SET8, SETD8, H4 K20 HMTase, H4 K20 specific histone methyltransferase, H4-K20-HMTase SETD8, Histone H4 K20 methyltransferase, Histone lysine N methyltransferase H4 lysine 20 specific, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, N-lysine methyltransferase SETD8, Pr SET 7, Pr SET7, PR-Set7, PR/SET domain containing protein 07, PR/SET domain containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PrSET7, SET 07, SET 8, SET domain containing (lysine methyltransferase) 8, SET domain containing 8, SET domain containing lysine methyltransferase 8, SET domain containing protein 8, SET domain-containing protein 8, SET07, SET8, SETD 8, setd8, SETD8,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: