Product Description
mGluR-5 Rabbit monoclonal Antibody | BS9933M | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC/IF IHC FC
Application Range: WB: 1:1000-1:2000 ICC/IF: 1:50-1:200 IHC: 1:200-1:500 FC: 1:50-1:100
Background: The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors) . The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of mGluR-5 and does not cross-react with related proteins.
Molecular Weight: ~ 132 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Metabotropic glutamate receptor 5; mGluR5; GRM5; GPRC1E; MGLUR5
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: