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Product Description
Nephrin polyclonal Antibody | BS90928 | Bioworld
Host: Rabbit
Reactivity: Human, Rat
Application: WB ICC
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200
Background: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. A defect in the gene for nephrin, NPHS1, is associated with congenital nephrotic syndrome of the Finnish type and causes massive amounts of protein to be leaked into the urine, or proteinuria. Nephrin is also required for cardiovascular development. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Specificity: Nephrin polyclonal Antibody detects endogenous levels of Nephrin protein.
Molecular Weight: 160 kDa, predicted band size 136 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: NPHS1, NPHN, CNF, Nephrin, Nephrosis 1 congenital Finnish type, Nephrosis 1, congenital, Finnish type (nephrin), NPHN, NPHN, NPHS 1, Nphs1, Renal glomerulus specific cell adhesion receptor, Renal glomerulus-specific cell adhesion receptor Antibody
Immunogen: Recombinant protein within human Nephrin aa 1000-1250.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein affinity purified.
Pathway:
