Product Description
PCNA polyclonal Antibody | BS91036 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP FC
Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:100-1:500 FC:1:50-1:100
Background: The proliferating cell nuclear antigen (PCNA), a protein synthesized in early G1 and S phases of the cell cycle, functions in cell cycle progression, DNA replication and DNA repair. In early S phase, PCNA exhibits granular distribution and is absent from the nucleoli; however, in late S phase, it relocates to the nucleoli. PCNA exists in two basic forms: one involved in ongoing DNA replication, which localizes specifically to the nucleus, and a second, soluble form, not implicated in constant synthesis. Interestingly, the latter form degrades in the presence of organic solvents, rendering it undetectable by histological methods in tissues using organic fixatives, and thus also providing a method of visualizing only the synthesizing form.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PCNA polyclonal Antibody detects endogenous levels of PCNA protein.
Molecular Weight: 29 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PCNA, ATLD2, cb16, Cyclin, DNA polymerase delta auxiliary protein, etID36690.10, fa28e03, fb36g03, HGCN8729, MGC8367, Mutagen-sensitive 209 protein, OTTHUMP00000030189, OTTHUMP00000030190, PCNA, Pcna/cyclin, PCNA, PCNAR, Polymerase delta accessory protein, Proliferating cell nuclear antigen, wu:fa28e03, wu:fb36g03,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,T cell receptor signaling,