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Product Description
PMP22 polyclonal Antibody | BS91094 | Bioworld
Host: Rabbit
Reactivity: Human, Rat
Application: WB ICC IHC FC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: PLP (myelin proteolipid protein or lipophilin) is a major constituent of myelin. The two isoforms of the myelin proteolipid protein, PLP and DM20, are very hydrophobic integral membrane proteins that account for about half of the protein content of adult CNS myelin. A mutation in the gene which encodes PLP is linked to Pelizaeus-Merzbacher disease (PMD), a chronic infantile type of diffuse cerebral sclerosis. The gene which encodes PLP maps to human chromosome Xq13-q22. The glycoprotein zero (also designated P-zero or myelin peripheral protein) is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peri-pheral nerves. Zero is an integral membrane glycoprotein whose expression is restricted to Schwann cells. The gene which encodes zero maps to human chromosome 1q22. PMP22 (peripheral myelin protein 22) is a growth-regulated membrane protein which is expressed by Schwann cells and is localized mainly in compact peripheral nervous system myelin. The gene which encodes PMP22 maps to human chromosome 17p11.2.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PMP22 polyclonal Antibody detects endogenous levels of PMP22 protein.
Molecular Weight: 22 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PMP-22, GAS-3, PMP22, GAS3, CMT1A, CMT1E, DSS, GAS-3, GAS3, Growth Arrest Specific 3, Growth arrest-specific protein 3, HMSNIA, HNPP, MGC20769, Peripheral myelin protein 22, PMP-22, PMP22, PMP22, Sp110, Trembler,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
