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Product Description
SP1 polyclonal Antibody | BS91276 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC
Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200
Background: Sp1 is a sequence-specific transcription factor that recognizes GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes. Sp1 was initially identified as a HeLa cell-derived factor that selectively activates in vitro transcription from the SV40 promoter and binds to the multiple GC boxes in the 21-bp repeated elements in SV40. The sequence specificity of DNA binding is conferred by Zn (II) fingers, whereas a different region of Sp1 appears to regulate the affinity of DNA binding. Sp1 belongs to a subgroup of transcription factors that are phosphorylated upon binding to promoter sequences. Evidence suggests that the early growth response gene, Erg-1 (also known as Zif268 or NGF1-A), may downregulate certain mammalian gene promoters by competing with Sp1 for binding to an overlapping binding motif. The gene encoding human Sp1 maps to chromosome 12q13.1.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: SP1 polyclonal Antibody detects endogenous levels of SP1 protein.
Molecular Weight: 81 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: SP1, SP 1, SP1, Sp1 transcription factor, SP1, Specificity protein 1, Transcription factor Sp1, TSFP 1, TSFP1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
