Product Description
SQSTM1 Mouse monoclonal Antibody | MB9009 | Bioworld
Host: Mouse
Reactivity: Human,mouse,rat
Application: WB ICC IHC FC
Application Range: WB: 1:500-1:1000 ICC: 1:200 IHC: 1:200 FC: 1:50-1:100
Background: Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of SQSTM1 and does not cross-react with related proteins.
Molecular Weight: ~ 62 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA; OSIL
Immunogen: This Antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to internal SQSTM1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: