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Product Description
TWIST1 monoclonal Antibody | LM1040 | Bioworld
Host: Mouse
Reactivity: Human,Mouse
Application: WB IHC ICC FC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TWIST1 monoclonal Antibody detects endogenous levels of TWIST1 protein.
Molecular Weight: ~ 22 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWIST
Immunogen: Purified recombinant fragment of human TWIST1 (AA: 9-74) expressed in E. Coli.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Purified Antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Pathway:
