Product Description
58K Golgi protein polyclonal Antibody | BS90009 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC FC
Application Range: WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:50-1:100
Background: 58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency [also known as formiminoglutamicaciduria (FIGLU-uria) ], an autosomal recessive disorder. Features of a severe phenotype include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay and no hematological abnormalities.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: 58K Golgi protein polyclonal Antibody detects endogenous levels of 58K Golgi protein protein.
Molecular Weight: 59 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: FTCD, LCHC1, FTCD, Formimidoyltetrahydrofolate cyclodeaminase, Formimidoyltransferase cyclodeaminase, Formiminotetrahydrofolate cyclodeaminase, Formiminotransferase cyclodeaminase, Formiminotransferase-cyclodeaminase, FTCD, FTCD, Glutamate formiminotransferase, Glutamate formyltransferase, LCHC 1, LCHC1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: