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Product Description
CHD3 (C-terminus) monoclonal Antibody | MB0061 | Bioworld
Host: Mouse IgG1
Reactivity: Human
Application: WB IHC FC
Application Range: WB: 1:1000 IHC: 1:500 FC: 1:50~100
Background: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of CHD3 (C-terminus) and does not cross-react with related proteins
Molecular Weight: Predicted band size:226KDa Observed band size:260KDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Chromodomain-helicase-DNA-binding protein 3; CHD-3; Hzfh; Zinc finger helicase; Mi2-alpha; ATP-dependent helicase CHD3
Immunogen: Synthetic peptide, corresponding to the C-terminus of Human CHD3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Contribution of Soluble Factors to EMT,
