Product Description
ATXN7 polyclonal Antibody | BS60839 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB
Application Range: WB: 1:500~1:1000
Background: The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract. SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product . Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype . Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ATXN7 polyclonal Antibody detects endogenous levels of ATXN7 protein.
Molecular Weight: ~ 95 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Ataxin-7; Spinocerebellar ataxia type 7 protein; ATXN7; SCA7
Immunogen: A synthetic peptide corresponding to residues in Human ATXN7.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: