Product Description
CD8B polyclonal Antibody | BS60358 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: The T cell receptor (TCR) is a heterodimercomposed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficientsignal transduction through the TCR. The TCR is expressed on T helper and T cytotoxiccellsthatcan be distinguished bytheir expression of CD4 and CD8. T helpercells express CD4 proteins and T cytotoxiccells display CD8. CD8 (also designated Leu 2 or T8), a cellsurface glycoprotein, is a two chain complex (αα or αβ) receptor that bindsclassI MHC molecules presented bythe antigen-presenting cell (APC) . A primaryfunction of CD8 is to facilitate antigen recognition bythe TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cellsmay be tomaintain lowlevels of HIV expression.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CD8B polyclonal Antibody detects endogenous levels of CD8B protein.
Molecular Weight: ~ 26 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: T-cell surface glycoprotein CD8 beta chain; CD_antigen=CD8b; CD8B ; CD8B1
Immunogen: A synthetic peptide corresponding to residues in Human CD8B.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: