Euro
USD
British Pound
NULL
Product Description
Cleaved-MMP-15 (Y132) polyclonal Antibody | BS7041 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB: 1:500~1:1000
Background: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) . MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Cleaved-MMP-15 (Y132) polyclonal Antibody detects endogenous levels of Cleaved-MMP-15 (60 kDa) protein.
Molecular Weight: ~ 61, 80 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Matrix metalloproteinase-15; MMP-15; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2; MMP15
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human MMP-15.
Conjugate: Unconjugated
Modification: Cleaved
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
